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Abatacept shows comparable efficacy to Humira in year two data in patients with moderate to severe rheumatoid arthritis

Bristol-Myers Squibb ( BMS ) has announced the results of year two data from AMPLE ( Abatacept Versus Adalimumab Comparison in Biologic-Naïve rheumatoid arthritis (RA) Subjects With Background Methotr ... read article

Pediatric Crohn's disease: Humira approved in Europe

European Commission has approved Humira ( Adalimumab ) for the treatment of pediatric patients aged six to 17 years with severely active Crohn's disease who failed, are intolerant to or have contraind ... read article

TNF-alpha blockers linked to reports of malignancies in children

The FDA ( Food and Drug Administration ) has received reports of malignancies in children using tumor necrosis factor alpha ( TNF ) blockers, raising concerns of an associated risk and prompting an in ... read article

Risk of tuberculosis with anti-TNF agents

Treatment with anti-tumor necrosis factor ( TNF ) agents is recognized as a risk factor for tuberculosis in patients with immune-mediated inflammatory diseases such as rheumatoid arthritis, ankylosing ... read article

Rheumatoid arthritis: Golimumab shows promising results in patients who have poor response to other TNF-alpha inhibitors

Golimumab ( Simponi ), a new tumour necrosis factor-alpha ( TNF-alpha ) blocker reduces the signs and symptoms of rheumatoid arthritis in patients who have previously received any other TNF-alpha inhi ... read article

Rheumatoid arthritis: treatment with the monoclonal anti-TNF-alpha antibodies Adalimumab and Infliximab linked to increased risk for herpes zoster

Use of monoclonal anti-TNF-alpha antibodies for the treatment of rheumatoid arthritis appears to be associated with an increased risk for herpes zoster. There has been evidence from some studies th ... read article

Risk of tuberculosis: higher for patients receiving anti-TNF monoclonal antibody therapy than for those receiving soluble TNF receptor therapy

Treatment with anti-TNF ( tumor necrosis factor ) blockers is recognized as a risk factor for tuberculosis ( TB ) in patients with immune-mediated inflammatory diseases such as rheumatoid arthritis, a ... read article

TNF blockers linked to increased risk of lymphoma, leukaemia and new-onset psoriasis

The FDA ( Food and Drug Administration ) is requiring the manufacturers of TNF blockers to update the Boxed Warning in the prescribing information to alert healthcare professionals of an increased ris ... read article

Anti-tumor necrosis factor alpha ( TNF-alpha ) antibodies for the treatment of rheumatoid arthritis appears to be associated with an increased risk for herpes zoster. There has been evidence from s ... read article

Anti-TNF-alpha therapy provides relief for children newly diagnosed with Crohn's disease

Children newly diagnosed with Crohn's disease may benefit from early treatment with the biologic drugs known as anti-TNF-alpha agents, according to a new study in Gastroenterology, the official journa ... read article