Search results for "Hypertension"

Rheumatoid arthritis: Rituximab linked to progressive multifocal leukoencephalopathy

A third case of progressive multifocal leukoencephalopathy ( PML ) has been reported in a patient with rheumatoid arthritis treated with Rituxan ( Rituximab; MabThera ). This occurred in a 73-year old ... read article

Kidney failure linked to Byetta, a drug for type 2 diabetes mellitus

The FDA ( Food and Drug Administration ) has completed a review of 78 cases of altered kidney function reported in patients with diabetes using Byetta ( Exenatide ). The cases were reported to FDAs A ... read article

Endothelin receptor antagonists: Darusentan for treatment of resistant hypertension

DAR-311, a Phase III clinical trial evaluating the endothelin receptor antagonist ( ERA ) Darusentan for the treatment of resistant hypertension, met its co-primary efficacy endpoints of change from b ... read article

Arcoxia: risk of hypertension-related adverse events

Healthcare professionals have previously been informed of the risk of hypertension-related adverse events associated with use of Etoricoxib ( Arcoxia ), and of the contraindication for use of Etoricox ... read article

Microangiopathic hemolytic anemia in patients treated with Bevacizumab plus Sunitinib

The safety and maximum tolerated dose ( MTD ) of Sunitinib malate( Sutent ) in combination with Bevacizumab ( Avastin ) has been assessed in patients with metastatic renal cell carcinoma ( mRCC ) in a ... read article

Acetylsalicylic acid does not prevent myocardial infarctions in patients with diabetes

Taking regular Acetylsalicylic acid ( Aspirin ) and antioxidant supplements does not prevent myocardial infarctions even in high risk groups with diabetes and asymptomatic arterial disease, and Acetyl ... read article

Chlorthalidone reduces risk for a type of heart failure that is more common among women

New research by The University of Texas School of Public Health has shown that a diuretic is particularly effective at reducing the risk for a type of heart failure that affects women more often than ... read article

Percutaneous coronary intervention: blood transfusion associated with increased risk of cardiac event

In an analysis that included more than two million patients who underwent a percutaneous coronary intervention ( PCI ) there was considerable variation in red blood cell transfusion practices among ho ... read article

Type 2 diabetes mellitus: effect of lowering blood pressure on risk for cognitive decline

Intensive blood pressure and cholesterol lowering was not associated with reduced risk for diabetes-related cognitive decline in older patients with long-standing type 2 diabetes mellitus, according t ... read article

Focus

Multiple sclerosis: FDA has approved Tecfidera

The FDA ( Food and Drug Administration ) has approved Tecfidera ( Dimethyl fumarate ) capsules to treat adults with relapsing forms of multiple sclerosis.Multiple sclerosis is a chronic, inflammatory, ... read article

Apremilast linked to significant and clinically meaningful improvements for the primary and major secondary endpoint in plaque psoriasis

Celgene has announced that statistical significance for the primary endpoint of PASI 75 at week 16 was achieved for patients receiving Apremilast 30 mg BID monotherapy in both the ESTEEM 1 and 2 phase ... read article

Kadcyla, a new treatment for late-stage breast cancer, approved by Food and Drug Administration

The U.S. Food and Drug Administration ) has approved Kadcyla ( Ado-Trastuzumab Emtansine ), a new therapy for patients with HER2-positive, late-stage ( metastatic ) breast cancer.HER2 is a protein inv ... read article

FISSION and NEUTRINO trial: Sofosbuvir has met primary endpoints for hepatitis C

Results from two Phase 3 studies, FISSION and NEUTRINO, evaluating a 12-week course of the once-daily nucleotide Sofosbuvir in combination with Ribavirin ( FISSION ) and in combination with Ribavirin ... read article

Increased risk of high-grade prostate cancer with 5-alpha reductase inhibitors

Men aged 55 and over with a normal digital rectal examination and PSA less than or equal to 3.0 ng/mL at baseline taking Finasteride 5 mg/day ( 5 times the dose of Propecia ) in the 7-year Prostate Ca ... read article

Castration-resistant prostate cancer: Cabozantinib linked to high rates of complete or partial bone scan resolution, pain relief, improvements in hemoglobin, and tumor regression

Exelixis has reported updated interim data from the cohort of patients with metastatic castration-resistant prostate cancer ( CRPC ) treated with Cabozantinib ( XL184; Cometriq ) in an ongoing phase 2 ... read article